成人在线视频国产,伊人伊狠亚洲综合影院,亚洲国产天堂久久综合,欧美国产日韩综合

論文發(fā)表

70. Bin Tan^#, Qingbo Zhang^#, Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides, ACS chemical biology. 2020, doi.org/10.1021/acschembio.9b00997

69. Hongbo Jin, Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, and Changsheng Zhang*, Engineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing Chassis. Organic letters.  2020. 2020, 22, 5, 1731-1735

68. Bin Tan,^# Siqiang Chen,^# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang*. Heterologous Expression Leads to Discovery of Diversi？ed Lobophorin Analogues and a Flexible Glycosyltransferase. Org. Letts.doi.org/10.1021/acs.orglett.9b04597

2019

67. Zhiwen Liu^#, Liang Ma^#, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Yuchan Chen, Weimin Zhang, Changsheng Zhang*. Functional characterization of the halogenase SpmH and discovery of new deschloro-tryptophan dimers. Organic & biomolecular chemistry. 2019, 17(2): 1053-1057.

66. Chunshuai Huang^#, Chunfang Yang^#, Zhuangjie Fang, Liping Zhang, Wenjun Zhang, Yiguang Zhu, Changsheng Zhang*. Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins. Marine drugs. 2019, 17(3): 150.

65. Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Yiguang Zhu, Liang Ma, Zhuangjie Fang, Changsheng Zhang*. Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster. The Journal of antibiotics. 2019, 72(5): 311.

64. Ziquan Yu, Haibo Zhang, Chengshan Yuan, Qingbo Zhang, Imran Khan, Yiguang Zhu, Changsheng Zhang*. Characterizing two cytochrome P450s in tiacumicin biosynthesis reveals reaction timing for tailoring modifications. Organic Letters. 2019, 21(18): 7679-7683

63. Liujuan Zheng,# Xiaodong Jiang,# Qingbo Zhang, Yiguang Zhu, Haibo Zhang, Wenjun Zhang, Kumar Saurav, Jinsong Liu, Changsheng Zhang*. Discovery and biosynthesis of neoenterocins indicate a skeleton rearrangement of enterocin. Organic Letters. 2019, 21(22): 9066-9070

62. Wei Liu, Wenjun Zhang, Hongbo Jin, Qingbo Zhang, Yuchan Chen, Xiaodong Jiang, Guangtao Zhang, Liping Zhang, Weimin Zhang, Zhigang She, Changsheng Zhang*. Genome mining of marine-derived Streptomyces sp. SCSIO 40010 leads to cytotoxic new polycyclic tetramate macrolactams. Marine Drugs. 2019, 17(12): 663

61. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, Changsheng Zhang*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research. 2019, DOI: 10.1080/14786419.2019.1616729

2018

60. Chunshuai Huang^#, Chunfang Yang^#, Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu* & Changsheng Zhang*. Molecular Basis of Dimer Formation during the Biosynthesis of Benzofluorene-Containing Atypical Angucyclines. Nature Communications. 2018, 9: 2088-2097.

59. Chunshuai Huang, Chunfang Yang, Yiguang Zhu*, Wenjun Zhang, Chengshan Yuan and Changsheng Zhang*. Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization. Frontiers in Chemistry. 2018, 6: 528-525.

58. Haibo Zhang, Xiaoxing Tian Xiaohui Pu, Qingbo Zhang, Wenjun Zhang, and Changsheng Zhang*. Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant. Journal of Natural Products. 2018, 81: 1219-1224.

57. Wenjun Zhang, Guangtao Zhang, Liping Zhang, Wei Liu, Xiaodong Jiang, Hongbo Jin, Zhiwen Liu, Haibo Zhang, Aihua Zhou, Changsheng Zhang*. New polycyclic tetramate macrolactams from marine-derived Streptomyces sp. SCSIO 40060. Tetrahedron. 2018, 74(47): 6839-6845.

2017

56. Subhasish Saha^#, Wenjun Zhang^#, Guangtao Zhang^#, Yiguang Zhu, Yuchan Chen, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang and Changsheng Zhang*. Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chemical Science. 2017, 8: 1607-1612.

55. Qingbo Zhang^#, Huixian Li^#, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu* and Changsheng Zhang*. Characterization of the Flavoenzyme XiaK as an N-Hydroxylase and Implications in Indolosesquiterpene Diversification. Chemical Science. 2017, 8(7): 5067-5077.

54. Wenjun Zhang^#, Chunfang Yang^#, Chunshuai Huang, Liping Zhang, Haibo Zhang, Qingbo Zhang, Chengshan Yuan, Yiguang Zhu, and Changsheng Zhang*. Pyrazolofluostatins A–C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160. Organic Letters.

53. Ruidong Chen^#, Qingbo Zhang^#, Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, and Changsheng Zhang*. Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides. Organic Letters. 2017, 19(20): 5697-5700.

52. Liang Ma, Wenjun Zhang, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Qingbo Zhang, Liping Zhang, Chengshan Yuan, Changsheng Zhang*. Identification and Characterization of a Biosynthetic Gene Cluster for Tryptophan Dimers in Deep Sea-Derived Streptomyces sp. SCSIO 03032. Applied Microbiology and Biotechnology. 2017, 101(15): 6123-6136.

51. Xiaodong Jiang, Qingbo zhang, Yiguagn Zhu, Fangling Nie, Zhengchao Wu, Chunfang Yang, Liping Zhang, Xinpeng Tian, ChangshengZhang*. Isolation, structure elucidation and biosynthesis of benzo[b]fluorene nenestatin A from deep-sea derived Micromonospora echinospora SCSIO 04089. Tetrahedron. 2017, 73(26): 3585-3590.

2016

50. Zhu Yiguang^#, Picard Mè^#, Zhang Qingbo, Barma J, Després X, Mei Xiangui, Zhang Liping, Duvignaud J, Couture M, Zhu Weiming, Shi Rong*, Zhang Changsheng*. Flavoenzyme CrmK-Mediated Substrate Recycling in Caerulomycin Biosynthesis. Chemical Science. 2016, 7(8), 4867-4874.

49. Zhu Yiguang^#, Xu Jinxin^#, Mei Xiangui^#, Feng Zhan, Zhang Liping, Zhang Qingbo, Zhang Guangtao, Zhu Weiming*, Liu Jinsong*, Zhang Changsheng*. Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis. ACS Chemical Biology. 2016, 11(4): 943-952.

48. Zhang Guangtao, Zhang Wenjun, Saha Subhasish, Zhang Changsheng*. Recent Advances in Discovery, Biosynthesis and Genome Mining of MedicinallyRelevant Polycyclic Tetramate Macrolactams. Current Topics in Medicinal Chemistry. 2016, 16(15): 1727-1739.

47. Zhang Haibo^#, Saurav Kumar^#, Yu Ziquan, Tibor Kurtan, Mándi Attila, Li Jie, Tian Xinpeng, Zhang Qingbo, Zhang Wenjun, Zhang Changsheng*. α-Pyrones with Diverse Hydroxy Substitutions from Three Marine-Derived Nocardiopsis Strains. Journal of Natural Products. 2016, 79(6): 1610-1618.

2015

46. Huixian Li^#, Yu Sun^#, Qingbo Zhang, Yiguang Zhu, Sumei Li, Ang Li, Changsheng Zhang*. Elucidating the cyclization cascades in xiamycin biosynthesis by substrate synthesis and enzyme characterizations. Organic Letters. 2015, 17(2): 306-309.

45. Chunfang Yang, Chunshuai Huang,Wenjun Zhang*,Yiguang Zhu ,Changsheng Zhang*. Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer. Organic Letters. 2015, 17(21): 5324-5327.

44. Yiguang Zhu^#, Wenjun Zhang^#, Yaolong Chen, Chengshan Yuan, Haibo Zhang, Guangtao Zhang, Liang Ma, Qingbo Zhang, Xinpeng Tian, Si Zhang, Changsheng Zhang*. Characterization of Heronamide Biosynthesis Reveals A Tailoring Hydroxylase and Indicates Migrated Double Bonds. ChemBioChem. 2015, 16(14): 2086-2093.

2014

43. Zhang Guangtao^#, Zhang Wenjun^#, Zhang Qingbo, Shi Ting, Ma Liang, Zhu Yiguang, Li Sumei, Zhang Haibo, Zhao Yilei, Shi Rong, Zhang Changsheng*. Mechanistic Insights Into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis. Angewandte Chemie International Edition. 2014, 53(19): 4840-4844.

42. Peng Fu^#, Yiguang Zhu^#, Xiangui Mei, Yi Wang, Haijian Jia, Changsheng Zhang* and Weiming Zhu*. Acyclic Congeners from Actinoalloteichus cyangriseus Provide Insights into Cyclic Bipyridine Glycoside Formation. Organic Letters. 2014, 16(16): 4264-4267.

41. Yaolong Chen^#, Wenjun Zhang^#, Yiguang Zhu*, Qingbo Zhang, Xinpeng Tian, Si Zhang,and Changsheng Zhang*. Elucidating Hydroxylation and Methylation Steps Tailoring Piericidin A1 Biosynthesis. Organic Letters. 2014, 16(3): 736-739.

40. Wenjun Zhang, Sumei Li, Yiguang Zhu, Yuchan Chen, Yaolong Chen, Haibo Zhang, Guangtao Zhang, Xinpeng Tian, Yu Pan, Si Zhang, Weimin Zhang, and Changsheng Zhang*. Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products. 2014, 77(2): 388-391.

39. Wenjun Zhang^#, Liang Ma^# , Sumei Li, Zhong Liu, Yuchan Chen , Haibo Zhang, Guangtao Zhang, Qingbo Zhang, Xinpeng Tian , Chengshan Yuan, Si Zhang , Weimin Zhang, and Changsheng Zhang*. Indimicins A–E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032. Journal of Natural Products. 2014, 77(8): 1887-1892.

2013

38. Ruidong Chen^#, Haibo Zhang^#, Gaiyun Zhang, Sumei Li, Guangtao Zhang, Yiguang Zhu, Jinsong Liu, Changsheng Zhang*. Characterizing Amosamine Biosynthesis in Amicetin Reveals AmiG as a Reversible Retaining Glycosyltransferase. Journal of the American Chemical Society. 2013, 135(33): 12152-12155.

37. Yiguang Zhu, Qingbo Zhang, Sumei Li, Qinheng Lin, Peng Fu, Guangtao Zhang, Haibo Zhang, Rong Shi, Weiming Zhu, Changsheng Zhang*. Insights into Caerulomycin A Biosynthesis:A Two-Component Monooxygenase CrmH-Catalyzed Oxime Formation. Journal of the American Chemical Society. 2013, 135(50): 18750-18753.

36. Sumei Li, Ji Xiao, Yiguang Zhu, Guangtao Zhang, Chunfang Yang, Haibo Zhang, Liang Ma, Changsheng Zhang*. Dissecting Glycosylation Steps in Lobophorin Biosynthesis Implies an Iterative Glycosyltransferase. Organic Letters. 2013, 15(6): 1374-1377.

35. Zhengchao Wu, Sumei Li, Jie Li, Yuchan Chen, Kumar Saurav, Qingbo Zhang, Haibo Zhang, Wenjun Zhang, Weimin Zhang, Si Zhang, Changsheng Zhang*. Antibacterial and Cytotoxic New Napyradiomycins from the Marine-Derived Streptomyces sp. SCSIO 10428. Marine Drugs. 2013, 11(6): 2113-2125.

34. Ji Xiao, Qingbo Zhang, Yiguang Zhu, Sumei Li, Guangtao Zhang, Haibo Zhang, Kumar Saurav, Changsheng Zhang*. Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis. Applied Microbiology and Biotechnology. 2013, 97(20): 9043-9053.

33. Zhengchao Wu, Sumei Li, Sangjip Nam, Zhong Liu, Changsheng Zhang*. Nocardiamides A and B, Two Cyclohexapeptides from the Marine-Derived Actinomycete Nocardiopsis sp. CNX037. Journal of Natural Products. 2013: 76: 694-701.

32. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu,Si Zhang, Weimin Zhang, Changsheng Zhang*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. Journal of Antibiotics. 2013, 66(1): 31-36.

2012

31. Yiguang Zhu, Peng Fu, Qinheng Lin, Guangtao Zhang, Haibo Zhang, Sumei Li, Jianhua Ju, Weiming Zhu, Changsheng Zhang*. Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase. Organic Letters. 2012, 14(11): 2666-2669.

30. Wenjun Zhang, Zhong Liu, Sumei Li, Tingting Yang, Qingbo Zhang, Liang Ma, Xinpeng Tian, Haibo Zhang, Caiguo Huang, Si Zhang, Jianhua Ju, Yuemao Shen , and Changsheng Zhang*. Spiroindimicins A-D: new bisindole alkaloids from a deep-sea-derived actinomycete.. Organic Letters. 2012, 14(13): 3364-3367.

29. Qingbo Zhang, Huixian Li, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis. Organic Letters. 2012, 14 (24): 6142–6145.

28. Huixian Li^#, Qingbo Zhang^#, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, Changsheng Zhang*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society. 2012, 134(21): 8996-9005.

27. Gaiyun Zhang, Haibo Zhang, Sumei Li, Ji Xiao, Yiguang Zhu, Siwen Niu, Jianhua Ju, Changsheng Zhang*. Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation. Applied and Environmental Microbiology. 2012, 78(7): 2393-2401.

26. Qingbo Zhang, Attila Mandi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtan, Changsheng Zhang*. N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete. European Journal of Organic Chemistry. 2012, 27, 5256-5262.

25. Wenjun Zhang, Zhong Liu, Sumei Li, Yongzhi Lu, Yuchan Chen,Haibo Zhang, Guangtao Zhang, Yiguang Zhu,Gaiyun Zhang, Weimin Zhang,Jinsong Liu, and Changsheng Zhang*. Fluostatins I-K from the South China Sea-Derived Micromonospora rosaria SCSIO N160. Journal of Natural Product. 2012, 75(11): 1937-1943.

2011

24. Yi Xiao^#, Sumei Li ^#, Siwen Niu, Liang Ma, Guangtao Zhang, Haibo Zhang, Gaiyun Zhang, Jianhua Ju and Changsheng Zhang*. Characterization of Tiacumicin B Biosynthetic Gene Cluster Affording Diversified Tiacumicin Analogues and Revealing a Tailoring Dihalogenase, Journal of the American Chemical Society. 2011, 133(4): 1092-1105.

23. Siwen Niu^#, Tao Hu^#, Sumei Li, Yi Xiao, Liang Ma, Gaiyun Zhang. Haibo Zhang, Si Zhang, Xiaohong Yang and Changsheng Zhang*. Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Property and Reveals Substrate Promiscuity. ChemBioChem. 2011, 12(11): 1740-1748.

22. Sumei Li, Xinpeng Tian, Siwen Niu, Wenjun Zhang, Yuchan Chen, Haibo Zhang, Weimin Zhang, Wenjun Li, Si Zhang, Jianhua Ju and Changsheng Zhang*. Pseudonocardians A-C, New Diazaanthraquinone Derivatives from a Deep-Sea Actinomycete Pseudonocardia sp. SCSIO 01299. Marine Drugs. 2011, 9(8): 1428-1439.

21. Siwen Niu, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Weimin Zhang, Xiaohong Yang, Si Zhang, Jianhua Ju and Changsheng Zhang*. Lobophorins E and F, new spirotetronate antibiotics from a South China Sea-derived Streptomyces sp. SCSIO 01127. The Journal of Antibiotics. 2011, 64(11): 711-716.

20. Liping Gong, Yi Xiao, Qiang Liu, Sumei Li, Changsheng Zhang*, Jinsong Liu*. Preliminary X-ray crystallographic analysis of the glycosyltransferase from a marine Streptomyces species. Acta Crystallographica Section F-Structural Biology Communications. 2011, 67(1): 136-139.

19. Gavin J Williams, Jie Yang, Changsheng Zhang, Thorson Jon.S.*. Recombinant E. coli Prototype Strains for in Vivo Glycorandomization. ACS Chem. Biol., 2011, 6(1): 94-100.

2002-2010

18. Changsheng Zhang, Rocco Moretti, Jiqing Jiang, Thorson JS Jon S. Thorson*. The In Vitro Characterization of Polyene Glycosyltransferases AmphDI and NysDI. ChemBioChem. 2008, 9(15): 2506-2514.

17. Changsheng Zhang, Bitto Eduard, Goff Randal D, Singh, Shanteri, Bingman, Craig A, Griffith Byron R, Albermann Christoph, Phillips George N. Jr* and Jon S. Thorson*, Biochemical and Structural Insights of the Early Glycosylation Steps in Calicheamicin Biosynthesis. Chemistry & Biology. 2008, 15(8): 842-853.

16. Williams Gavin J., Goff Randal D., Changsheng Zhang, Jon S. Thorson*. Optimizing glycosyltransferase specificity via ‘hot spot’ saturation mutagenesis presents a new catalyst for novobiocin glycorandomization. Chemistry & Biology. 2008, 15(4): 393-401.

15. Singh Shanteri, McCoy, Jason G., Changsheng Zhang, Bingman Craig A., Phillips George N., Jr.*, Jon S. Thorson*. Structure and Mechanism of the Rebeccamycin Sugar 4-O-Methyltransferase RebM. Journal of Biological Chemistry. 2008, 283(33): 22628-22636.

14. Changsheng Zhang, Qiang Fu, Albermann Christoph, Lingjun Li, Jon S. Thorson*, The In Vitro Characterization of the Erythronolide Mycarosyltransferase EryBV and Its Utility in Macrolide Diversification. ChemBioChem. 2007, 8(4): 385-390.

13. Changsheng Zhang, Albermann Christoph, Xun Fu, Jon S. Thorson*, The In Vitro Characterization of the Iterative Avermectin Glycosyltransferase AveBI Reveals Reaction Reversibility and Sugar Nucleotide Flexibility. Journal of the American Chemical Society. 2006, 128(51): 16420-16421.

12. Changsheng Zhang, Griffith Byron R, Qiang Fu, Albermann Christoph, Xun Fu, Lee In Kyoung, Lingjun Li, Jon S. Thorson*. Exploiting the Reversibility of Natural Product Glycosyltransferase-catalyzed Reactions. Science. 2006, 313(5791): 1291-1294.

11. Changsheng Zhang, Albermann Christoph, Xun Fu, Peters Noel R, Chisholm John D, Guisheng Zhang, Gilbert Eric J, Wang Peng George, Van Vranken DavidL, Jon S. Thorson*. RebG- and RebM-catalyzed Indolocarbazole Diversification. ChemBioChem. 2006, 7(5): 795-804.

10. Changsheng Zhang, Rachel L Weller, Jon S. Thorson, Scott R. Rajski*. Natural Product Diversification Using Non-natural Cofactor Analogues of S-adenosyl-L-methionine. Journal of the American Chemical Society. 2006, 128(9): 2760-2761.

9. Svetlana A. Borisova, Changsheng Zhang, Haruko Takahashi, Hua Zhang, Alexander W. Wong, Jon S. Thorson, Hung-wen Liu *. Substrate Specificity of the Macrolide-Glycosylating Enzyme Pair DesVII/DesVIII: Opportunities, Limitations and Mechanistic Hypotheses. Angewandte Chemie International Edition. 2006, 45(17): 2748-2753.

8. Qunjie Gao, Changsheng Zhang, Blanchard Sophie, Jon S. Thorson *. Deciphering indolocarbazole and enediyne aminopentose biosynthesis through comparative genomics: New insights and tools from the Actinomadura melliaura AT2433 biosynthetic locus. Chemistry & Biology. 2006, 13(7): 733-743.

7. Singh Shanteri, Hager Martin H., Changsheng Zhang, Griffith Byron R., Lee Min S, Hallenga Klaas, Markley John L. and Jon S. Thorson*. Structural insight into self-sacrifice mechanism of enediyne resistance. ACS Chem. Biol., 2006, 1(7): 451-460.

6. Fu X, Albermann C, Zhang C, Thorson JS*. Diversifying Vancomycin via Chemoenzymatic Strategies. Organic Letters. 2005, 7(8): 1513-1515.

5. Changsheng Zhang, Michael Podeschwa, Oliver Block, Hans Jpsef Altenbach, Wolfgang Piepersberg and Udo F Wehmeier*. Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110. FEBS Letters. 2003, 540(1-3): 53-57.

4. Changsheng Zhang, Michael Podeschwa, Hans Jpsef Altenbach, Wolfgang Piepersberg and Udo F Wehmeier*. The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase. FEBS Letters, 2003, 540(1-3): 47-52.

3. Xun Fu, Christoph Albermann, Jiqing Jiang, Jianchun Liao, Changsheng Zhang & Jon S. Thorson *. Antibiotic optimization via in vitro glycorandomization. Nature Biotechnology. 2003, 21(12): 1467-1469.

2. Changsheng Zhang, Ansgar Stratmann, Oliver Block, Brückner Ralph, Michael Podeschwa, Hans Jpsef Altenbach, Udo F. Wehmeier and Wolfgang Piepersberg*. Biosynthesis of the C7-cyclitol Moiety of Acarbose in Actinoplanes Species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. Journal of Biological Chemistry.2002, 277(25): 22853-22862.

1. Changsheng Zhang, Ansgar Stratmann, Oliver Block, Brückner Ralph, Michael Podeschwa, Hans Jpsef Altenbach, Udo F. Wehmeier and Wolfgang Piepersberg*. Biosynthesis of the C7-cyclitol Moiety of Acarbose in Actinoplanes Species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. The Journal of Biological Chemistry. 2002, 277(25): 22853-22862.

授權專(zhuān)利

1. 張長(cháng)生，李慧賢，張慶波，李蘇梅，朱義廣，張光濤，張海波，田新朋，張偲，鞠建華，廈霉素A和氧廈霉素的生物合成基因簇及其應用，ZL201210146664.x；

2. 張長(cháng)生，張海波，李蘇梅，張改云，張光濤，朱義廣，陳瑞東，肖吉，鞠建華，友菌素的生物合成基因簇及其應用，ZL201210030835.2；

3. 張長(cháng)生，張慶波，李蘇梅，田新朋，張文軍，張海波，李惠賢，張偲，鞠建華，鏈霉菌和吲哚倍半萜類(lèi)化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應用，ZL201210146953.x；

4. 張長(cháng)生，張文軍，李蘇梅，張海波，張改云，張光濤，朱義廣，一種小單孢菌及利用該菌制備多種抗生素的方法，ZL201210467946.X；

5. 張長(cháng)生，李蘇梅，田新朋，牛四文，張文軍，鞠建華，張偲一種鏈霉菌及利用該菌發(fā)酵制備抗霉素類(lèi)抗生素的工藝，ZL201010520348.5；

6. 張長(cháng)生，李蘇梅，田新朋，牛四文，鞠建華，張偲，一種鏈霉菌及利用該菌制備多種抗生素的工藝，ZL201010603179.1；

7. 張長(cháng)生，李蘇梅，肖毅，牛四文，鞠建華，四種臺勾霉素類(lèi)化合物及其制備方法和在制備抗菌藥物中的應用，ZL201010526416.9；

8.張長(cháng)生，李蘇梅，田新朋，張文軍，張海波，張光濤，張偲，鞠建華，抗生素Pseudonocardian A和B及其制備方法和在制備抗菌、抗腫瘤藥物中的應用，ZL201110231993.X；

9. 張長(cháng)生，李蘇梅，牛四文，田新朋，張光濤，張海波，張偲，鞠建華，抗生素Lobophorin E和F及其制備方法和在制備抗菌、抗腫瘤藥物中的應用，ZL201110149558.2；

10. 張長(cháng)生，牛四文，胡濤，李蘇梅，肖毅，馬亮，張光濤，張海波，鞠建華，六種臺勾霉素類(lèi)化合物及其制備方法和在制備抗菌藥物中的應用，ZL201110104051.5；

11. 張長(cháng)生，張文軍，田新朋，李蘇梅，張慶波，馬亮，張海波，張偲，鞠建華，鏈霉菌、抗腫瘤化合物Spiroindimycin A-D及其制備方法和應用，ZL201210087537.7；

12. 張長(cháng)生，肖毅，李蘇梅，牛四文，張光濤，張海波，胡濤，鞠建華，臺勾霉素的生物合成基因簇及其應用，ZL201010592416.9；

13. 張長(cháng)生，張文軍，田新朋，李蘇梅，張慶波，馬亮，張海波，張偲，鞠建華，鏈霉菌、抗腫瘤化合物Spiroindimycin A-D及其制備方法和應用，特許第5826406（PCT國際專(zhuān)利（日本）；

14. 張長(cháng)生，吳正超，李蘇梅，李潔，庫馬·薩烏拉夫，張慶波，張海波，張文軍，張偲，鏈霉菌、新化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應用，ZL201310180810.5；

15. 張長(cháng)生，張光濤，張文軍，張慶波，朱義廣，張海波，李蘇梅，馬亮，一種斑鳩霉素的生物合成基因簇及其應用，ZL201410120626.6；

16. 張長(cháng)生，張文軍，馬亮，李蘇梅，張慶波，張海波，張光濤，抗生素Indimicins A-E及其制備方法和在制備抗腫瘤藥物中的應用，ZL201410214540.X；

17. 張長(cháng)生，張文軍，楊春芳，黃春帥，朱義廣，抗生素difluostatin A及其制備方法和在制備抗菌藥物中的應用，ZL201510650332.9；

18. 張長(cháng)生，朱義廣，張文軍，陳耀龍，袁呈山，張海波，張光濤，張慶波，一種大環(huán)內酰胺類(lèi)化合物heronamides的生物合成基因簇及其應用，ZL201510404149.0；

19. 張長(cháng)生，吳正超，李蘇梅，李潔，庫馬·薩烏拉夫，張慶波，張海波，張文軍，張偲，新化合物及其制備方法和在制備抗菌抗腫瘤藥物中的應用，ZL201510512966.8；

20. 張長(cháng)生，張光濤，張文軍，張慶波，朱義廣，張海波，李蘇梅，馬亮，一種斑鳩霉素的生物合成基因簇及其應用，ZL201510648554.7；

21. 張長(cháng)生，張光濤，張文軍，朱義廣，袁呈山，張慶波，張海波，張麗萍，一種帕克特酰胺的生物合成基因簇及其應用，ZL 201610807614X；

22. 張長(cháng)生，張文軍，楊春芳，黃春帥，張麗萍，張海波，抗生素pyrazolofluostatin A-C及其制備方法和應用，ZL 201710008234.4。