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        張慶波
        
              	  
        
                         
        
                           
        
                               
        		
                         
        
                         
        
                           
        所系名稱(chēng)
        		
                           中國科學(xué)院南海海洋研究所，中國科學(xué)院熱帶海洋生物資源與生態(tài)重點(diǎn)實(shí)驗室
                         
        
                         
        
                           
        性別
        		
                           男
                         
        
                         
        
                           
        專(zhuān)業(yè)名稱(chēng)
        		
                           海洋生物學(xué)/生物技術(shù)與工程
                         
        
                         
        
                           
        技術(shù)職務(wù)
        		
                           項目研究員
                         
        
                         
        
                           
        行政職務(wù)
        		
                           無(wú)
                         
        
                         
        
                           
        Mail地址
        		
                           zhangqingbo@scsio.ac.cn
                         
        
                         
        
                           
        指導博士生總數
        		
                           
        0
        		
                           
        指導碩士生總數
        		
                           
        2
        		
                           
        通訊地址
        		
                           廣州市海珠區新港西路164號
                         
        
                         
        
                           
        目前博士生數
        		
                           
        0
        		
                           
        目前碩士生數
        		
                           
        2
        		
                           
        郵政編碼
        		
                           510301
                         
        
                        
                         
        
                           
        研究方向
        		
                           
        海洋微生物來(lái)源新藥源分子和新功能酶的發(fā)現
        		
                         
        
                         
        
                           
        研究工作
        		
                           
        海洋微生物來(lái)源新藥源分子和新功能酶的發(fā)現 
        （1）海洋新藥源分子的發(fā)現：采用隨機篩選和基因組挖掘相結合的方法發(fā)現海洋微生物來(lái)源新藥源分子，并提高其產(chǎn)量。 
        （2）海洋新功能酶的發(fā)現：揭示海洋微生物合成天然產(chǎn)物的新機制，發(fā)掘具有綠色催化功能的酶。
        		
                         
        
                         
        
                           
        獲獎情況
        		
                           
        1. 中國科學(xué)院院長(cháng)優(yōu)秀獎（2013）
        2. 廣州市“珠江科技新星”（2016）
        3. 中國科學(xué)院南海海洋研究所“南海新星”（2018）
        		
                         
        
                         
        
                           
        指導研究生情況
        		
                           
        2023級碩士：楊紫怡
        2024級碩士：陳玄皓
        		
                         
        
                         
        
                           
        個(gè)人簡(jiǎn)介
        		
                           
        工作經(jīng)歷
        2017.01-至今：中國科學(xué)院南海海洋研究所，副研究員，項目研究員
        2013.05-08和2014.09-11：德國馬堡大學(xué)，短期研修生
        2013.07-2016.12：中國科學(xué)院南海海洋研究所，助理研究員
        2008.07-2010.07：廣東省微生物研究所，研究助理
         
        教育背景
        2010.07-2013.07：中國科學(xué)院大學(xué)（南海海洋研究所）海洋生物學(xué)，博士
        2005.09-2008.07：中山大學(xué)藥學(xué)院，生藥學(xué)，碩士
        2001.09-2005.07：湖南中醫藥大學(xué)藥學(xué)院，中藥學(xué)，學(xué)士
        		
                         
        
                         
        
                           
        科研成果
        		
                           
        1.已發(fā)表文章66篇、授權專(zhuān)利13件。
        代表性論文（第一作者或通訊作者20篇）：# (第一作者)，* (通訊作者)
        1. Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351.
        2. Bin Tan,# Liping Zhang,# Qingbo Zhang,# Siqiang Chen, Weiliang Xiong, Yiguang Zhu*, Changsheng Zhang*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27): e202302043. 
        3. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang,* Qingbo Zhang*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979-985.
        4. Ziqian Cheng,# Qingbo Zhang,# Jing Peng,# Xiaoyang Zhao, Liang Ma, Changsheng Zhang*, Yiguang Zhu*. Genomics-Driven discovery of benzoxazole alkaloids from the marine-derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821.
        5. Bin Tan,# Qingbo Zhang,# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu*, and Changsheng Zhang*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, (12): 1478–1484.
        6. Bin Tan, Qingbo Zhang,* Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84.
        7. Bin Tan, Qingbo Zhang,* Liping Zhang, Yiguang Zhu, Changsheng Zhang*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103.
              8. Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang*. Antifungal macrolides kongjuemycins from coral-associated rare actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic  Letters, 2022, 24 (19): 3482–3487.
        9. Xiaodong Jiang,# Zhuangjie Fang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021, 19 (19): 4243-4247.
        10. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, and Changsheng Zhang*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194.
        11. Yiguang Zhu,# Qingbo Zhang,# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,* and Changsheng Zhang*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069.
        12. Zhuangjie Fang,# Xiaodong Jiang,# Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130.
        13. Bin Tan,# Qingbo Zhang,# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773.
        14. Bin Tan,# Siqiang Chen,# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang and Changsheng Zhang*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066.
        15. Ruidong Chen,# Qingbo Zhang,# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700.
        16. Qingbo Zhang,# Huixian Li,# Lu Yu, Yu Sun, Yiguang Zhu, 
        Hanning Zhu, Liping Zhang, ShuMing Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu,* and Changsheng Zhang*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077.
        17. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36.
        18. Qingbo Zhang,# Huixian Li,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145.
        19. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,* Changsheng Zhang*. N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012 (27): 5256-5262.
              20. Huixian Li,# Qingbo Zhang,# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005.